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As the title says WineVDM allows you to run 16-bit apps on 64-bit Windows.
DL link: https://github.com/otya128/winevdm/releases
Microsoft Visual C++ Redist (download x86 only!): https://www.microsoft.com/en-us/download/details.aspx?id=52685
Video by Micheal MJD:
Screenshot of Chip's Challenge running on Windows 10 x64 build 18305: