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What should I download to get MS DOS 6.22
This depends on your preferred language. Assuming "English" I recommend "Microsoft MS-DOS 6.22 Plus Enhanced Tools (3.5-1.44mb)", while all "Upgrade" versions require an already installed MS-DOS on your (real or virtual) hard disk.
With a trick you may fool the "Upgrade" versions which usually do not allow you to install it on a blank HDD. For this you have to press and hold the "Shift" key on your keyboard while booting from the first floppy. Next step is "fdisk" to create a primary partition (if your HDD is complete empty), which requires a reboot afterwards. Keep the first floppy in the drive and boot while holding "Shift" again. Then run "sys c:" (without the quotes) from the command prompt and boot again from the first floppy, but this time WITHOUT pressing "Shift". Voila, the Setup will do the job now.
From MS-DOS 6 upgrade (6.0 / 6.2 / 6.21 / 6.22) it is possible to installed on blanked HDD drive.
But you should make partition and make system boot from HDD that MSCdebug said.
(If not SETUP.EXE reguse to install MS-DOS Upgrade on HDD)
I added install processing as screenshot.